Laurel Halo - "Supersymmetry" (2010)
Irresistible.
Martha & The Vandellas - "Third Finger, Left Hand" (1967)
I picked this one because a back-in-the-day pre-gone-down-the-drain Morrissey said it was his "favourite record of all time, which can lift me from the most doom-laden depression" and listed it as a "single to be cremated with". But I prefer
"Live Wire" (1964),
"(Love Is Like A) Heat Wave" (1963),
"Jimmy Mack" (1967)... Actually,
Laura Nyro and Labelle's take on "Jimmy Mack" (1971) is the fucking definitive one.